Charles was born in Queensberry House in Edinburgh on 24 November 1698,[2] the younger son of James Douglas, 2nd Duke of Queensberry, 1st Duke of Dover, and his wife Mary Boyle, daughter of Charles Boyle, 3rd Viscount Dungarvan,[citation needed] On 17 June 1706, while still a child, Charles was created in his own right Lord Douglas of Lockerbie, Dalveen and Thornhill, Viscount of Tiberris and Earl of Solway.
In 1711, he succeeded his father as Duke of Queensberry, superseding his mentally ill older brother James Douglas.
In 1746, the Duke of Queensberry invested in the British Linen Company as one of the original proprietors, hoping to aid the development of the Scottish economy through the manufacturing of linen to be sold to the American colonies and Caribbean plantations.
He was appointed Keeper of the Great Seal of Scotland in 1761 and was Lord Justice General from 1763 until his death in 1778.
They had two sons, who both predeceased him:[citation needed] This biography of a duke or duchess in the peerage of Scotland is a stub.