Charles E. Cunningham (July 1, 1823 – April 21, 1895) was an American politician who is best known for being the Union Labor Party's nominee for Vice President of the United States in the 1888 election.

He went to St. Louis, Missouri in 1862 and moved to Little Rock, Arkansas after the end of the American Civil War.

He ran for Governor of Arkansas as the candidate of the Agricultural Wheel party in 1886, receiving 11.7 percent of the vote.

At that year's Union Labor National Convention in May, Illinois State Senator Alson Streeter was unanimously nominated as their candidate for president.

After Evans declined the party's nomination, Cunningham became the vice presidential candidate.