Charles Edward Kiefner (November 25, 1869 – December 13, 1942) was a U.S. Representative from Missouri's 13th congressional district.

Born in Perryville, Missouri to German immigrants,[1] Kiefner attended the public school system.

He engaged in the retail lumber business and also in road construction.

Kiefner served as Mayor of Perryville from 1900 to 1902 and was a member of the Missouri House of Representatives from 1902 to 1908.

He resumed the lumber and banking business in Perryville, Missouri, until his death on December 13, 1942.