Perryville is a city in Perry County, Missouri, United States.

[5] Perryville was selected the county seat of Perry County by Robert T. Brown, Joseph Tucker, and Thomas Riney, who had been appointed to select the seat of justice.

[6] In 1821, Bernard Layton deeded 51 acres (210,000 m2) to the commissioners in exchange for one town lot.

[7][8] An early store in Perryville was a log structure built by Jean Ferdinand Rozier on the north side of the square.

[citation needed] As both merchandisers and consumers grew in sophistication, so did the types of establishments in the county.

Built in 1843, the Hoose Hotel, often called the "white house",[5] was a prominent structure in early commercial days.

Fourth Class City status was attained in 1879 and the following year Charles A. Weber was elected its first mayor.

[11] On February 28, 2017, an EF4 tornado tore through Perryville, causing widespread EF3 and some EF4 damage in and around the city.

Perryville is located in central Perry County approximately seven miles from the Mississippi River.

Cinque Hommes Creek flows past the south side of the city.

[13] The 2020 United States census[17] counted 8,555 people, 3,357 households, and 2,107 families in Perryville.

Of all households, 30.9% consisted of individuals and 12.2% had someone living alone who was 65 years of age or older.

The racial makeup of the city was 95.33% White, 0.75% Black or African American, 0.39% Native American, 0.90% Asian, 0.07% Native Hawaiian or Pacific Islander, 1.28% from other races, and 1.28% from two or more races.

31.1% of all households were made up of individuals, and 14.4% had someone living alone who was 65 years of age or older.

30.4% of all households were made up of individuals, and 15.6% had someone living alone who was 65 years of age or older.

Two of the largest employers in the city are TG Missouri, a division of Toyoda Gosei, and Gilster-Mary Lee.

[27] The 880th Engineer Team (HAUL) of the Missouri Army National Guard is based in Perryville.