Charles William Grube (June 11, 1904 – January 21, 1976) was an American football player.

Grube was born in 1904 in Saginaw, Michigan, attended Arthur Hill High School in that city.

At the time, one sports writer noted: "Grube has all the essentials of a good end ...

[3] Grube later played professional football for the Detroit Panthers in 1926.

[5] In the 1930s, Grube was a football coach at Eastern High School in Lansing, Michigan and his alma mater, Arthur Hill High School, in Saganaw.