Charles Louis Upton (September 10, 1870 – May 25, 1936) was an American physician and college football coach.
He was the fourth head football coach at Vanderbilt University, serving for one season, in 1895, and compiling a record of 5–3–1.
Upton was born on September 10, 1870, in Shelburne Falls, Massachusetts.
He graduated from Amherst College and received a medical degree from the University of Pennsylvania.
Upton practiced medicine in Massachusetts.