William J. Keller (c. 1869 – October 2, 1924) was an American college football player and coach and otolaryngologists.

He was the second head football coach at Vanderbilt University, serving for one season, in 1893, compiling a record of 6–1.

Keller also played and served as team captain for the Vanderbilt Commodores for both the 1893 and 1894 seasons.

[1] Before coming to Vanderbilt, he played at the International Young Men's Christian Association Training School—now known as Springfield College—in Springfield, Massachusetts for Amos Alonzo Stagg.

He earned a medical degree from the Vanderbilt University School of Medicine.