[1] Anthony Wood recorded that he left Oxford in debt; he went to Jesus College, Cambridge, and graduated M.A.

When Wood wrote his Athenæ Oxonienses, Leigh was practising in London; but he lived at Manchester at a later date, and had an extensive practice in Lancashire.

[1] Some of Leigh's papers read before the Royal Society are printed in the Philosophical Transactions, and he published the following separate works: He also wrote three pamphlets in 1698 in answer to Richard Boulton on the Heat of the Blood, and one in reply to John Colebatch on curing the bite of a viper.

Thomas Dunham Whitaker later wrote slightingly of Leigh's "want of literature".

Leigh married Dorothy, daughter of Edward Shuttleworth of Larbrick, Lancashire, with whom he received a moiety of the manor of Larbrick, afterwards surrendered in payment of a debt owing by Leigh to Serjeant Reginald Bretland.