Bo was born on 29 October 1948, in Monhla Village, Shwebo District, Sagaing Region, Myanmar to parents John and Juliana Aye Tin.

[2] From 1962 to 1976, Bo studied at the Nazareth Aspirantate, a Salesian seminary, in Anisakan village, near Maymyo (now Pyin Oo Lwin).

On 17 March 2001, Pope John Paul II named him a member of the Pontifical Council for Interreligious Dialogue.

[6] At that ceremony, he was assigned the titular church of Sant’Ireneo a Centocelle[7] In April 2015 Pope Francis named him a member of the Congregation for Institutes of Consecrated Life and Societies of Apostolic Life and the Pontifical Council for Culture, and in July 2016 a member of the Secretariat for Communications.

[10] He was elected to a three-year term as head of the Federation of Asian Bishops' Conferences (FABC) in the fall of 2018.