Charles Samuel Peskin (born April 15, 1946) is an American mathematician known for his work in the mathematical modeling of blood flow in the heart.
From this work has emerged an original computational method for fluid-structure interaction that is now called the “immersed boundary method", which allows the coupling between deformable immersed structures and fluid flows to be handled in a computationally tractable way.
With his students and colleagues, Peskin also has worked on mathematical models of such systems as the inner ear, arterial pulse, blood clotting, congenital heart disease, light adaptation in the retina, control of ovulation number, control of plasmid replication, molecular dynamics, and molecular motors.
He has been a productive educator of applied mathematicians, and has advised more than fifty graduate students as of 2014.
Their son Eric is the manager of High Performance Computing at New York University.