Charles Sackville, 2nd Duke of Dorset PC (6 February 1711 – 5 January 1769), styled as Lord Buckhurst from 1711 to 1720 and the Earl of Middlesex from 1720 to 1765, was a British politician who sat in the House of Commons between 1734 and 1765.

In that year, he succeeded his father as Duke of Dorset, and also as Lord Lieutenant of Kent, and was made a Privy Councillor in 1766.

After a second grand tour to continental Europe in 1737 and 1738, he returned to England in January 1739 and staged an opera, Angelico e Medoro, with music by Giovanni Battista Pescetti from a libretto by Metastasio at Covent Garden.

This was intended as a showcase for the (apparently limited) talents of the soprano Lucia Panichi, La Muscovita, who was Middlesex's mistress from about 1739 to about 1742.

He also had the ambition to revive full-scale Italian opera in London, which Johann Jakob Heidegger had recently abandoned at the King's Theatre, Haymarket because of its expense.

Like other members of his family, particularly his brother and his nephew, Sackville had an interest in cricket but did not achieve their level of involvement, probably because of his political activity.