Charles Stetson (November 2, 1801 – March 27, 1883) was a United States representative from Maine, and the eldest member of a powerful Bangor political family.

His father Simeon Stetson (b. Braintree, Massachusetts) kept a store and a sawmill, and built vessels for the West India Trade.

He moved to Bangor, adjoining Hampden, in 1833, as that city grew rapidly into the region's largest port.

He affiliated with the Republican Party in 1860, as had most local politicians, including fellow Hampdenite Hannibal Hamlin, who became Lincoln's Vice President.

The Stetson Block on Exchange Street was burned in the Great Fire of 1911 and quickly replaced by a building of the same name, and in the same location, from a design by local architect Wilfred E. Mansur.

A second and larger Stetson Block was built in 1913 on Central Street, from a design by Parker, Thomas, and Rice of Boston.