Charles W. Russell House is a historic home located at Wheeling, Ohio County, West Virginia.

It was built in 1848, and is a 2+1⁄2-story, four-bay-wide, Greek Revival-style brick dwelling.

It was constructed as an office and residence for attorney Charles W. Russell (1818-1867).

It was part of the military headquarters established at Wheeling during the first winter of the American Civil War.

This article about a property in Ohio County, West Virginia on the National Register of Historic Places is a stub.