The William Miles Tiernan House, also known as the Tiernan-Riley House, is a historic home located at Wheeling, Ohio County, West Virginia.

It was built in 1900–01, and is a 2+1⁄2-story, L-shaped, Georgian Revival-style brick dwelling.

It features two-story Ionic order pilasters that flank the one-story entrance portico.

The house was built for William M. Tiernan, who was vice-president of the Bloch Brothers Tobacco Company.

This article about a property in Ohio County, West Virginia on the National Register of Historic Places is a stub.