Charles Lafayette Witherow (April 1852 – July 3, 1948) was an American professional baseball pitcher.

He was the starting pitcher for the Nationals on July 1, but only lasted one inning as he gave up four hits and five runs, two runs which were earned.

At the time of his death, Charles Witherow was the last surviving participant of the National Association.

At the time of his death he had been the last living player from the 1875 season.

This biographical article relating to an American baseball pitcher born in the 1850s is a stub.