Woodson played college football for the Michigan Wolverines, three times selected to the All-Big Ten team, twice earning All-American honors.

[3] In his senior season, he was a USA Today All-America selection and Parade High School All-American and recorded 2,028 yards and 230 points.

He was also a finalist for the Jim Thorpe Award and named to the All-Big Ten First-team by both the conference coaches and the media.

[9] In 1997, Woodson became the third Michigan player in program history to win the Heisman Trophy, joining Tom Harmon (1940) and Desmond Howard (1991).

[9] Woodson finished his three-year collegiate career with 18 interceptions, currently second all-time in University of Michigan football history.

Woodson later stated that he tried to do Desmond Howard's famous "pose" after scoring the touchdown, but failed after his teammates mobbed him in the end zone.

[30] After recovering from his shoulder injury, Woodson missed the last three games of the regular season, suffering from a cracked fibula bone in his right leg.

In the Super Bowl, Woodson showed signs of his injury, but still recorded an interception in a losing effort against the Tampa Bay Buccaneers.

[48] On April 26, 2006, Woodson and the Green Bay Packers reached a 7-year contract agreement that could be worth as much as $52.7 million with bonuses and incentives.

The cornerback has since lauded the Packers organization, Mike McCarthy, and the people of Wisconsin for having faith in him, and has declared that "it was truly a blessing coming to Green Bay.

"[50] Free of any major injuries during the 2006 season, Woodson (tied with Walt Harris formerly of the San Francisco 49ers) led the National Football Conference with eight interceptions.

[53] On October 14, 2007, Woodson picked up a Santana Moss fumble and returned it 57 yards for a go-ahead touchdown in a 17–14 victory over the Washington Redskins.

Woodson was named the NFC's Defensive Player of the Week for his performance versus the Redskins, which was the first time he had received that award.

[55] On November 4, Woodson had a 46-yard interception return for a touchdown with 59 seconds remaining in the fourth quarter to seal a win over the Kansas City Chiefs.

[60] On November 15, 2009, Woodson recorded nine tackles (two for loss), a sack, two forced fumbles and an interception in a 17–7 victory over the Dallas Cowboys.

He recorded seven tackles, one sack, one forced fumble and recovery (same play), four passes defended and two interceptions, one of which he returned for a touchdown.

He provided a huge performance, limiting Pro Bowler DeSean Jackson to just two catches (for 47 yards), and recorded five tackles in the Packers' win over the Philadelphia Eagles in the Wild Card Round on January 9, 2011.

[79] Woodson also played an important role in Dom Capers' defense in playoff victories against the Atlanta Falcons in the Divisional Round and the Chicago Bears in the NFC Championship and started against the Pittsburgh Steelers in Super Bowl XLV.

[80][81] With 1:54 before halftime of the Super Bowl, Woodson broke his collar bone while diving to successfully defend a pass intended for Mike Wallace.

[82] Barack Obama said if the Bears won the NFC Championship, that he would see them play in Super Bowl XLV, but he would not see Green Bay.

"[83][84] Engraved inside the Super Bowl 45 Ring is the numeral "1" along with the words "Mind, Goal, Purpose and Heart": the number and terms veteran cornerback Charles Woodson used during his memorable postgame locker room speech following the NFC Championship in Chicago.

[93][94] Woodson started the 2012 season in a different role for the Packers, hoping to fill the void left by free safety Nick Collins, who had been out of football for almost a year with a neck injury.

This saw Woodson in a Polamalu-like position of the Pittsburgh Steelers, lining up on either side ready to rush or drop back in coverage.

Against the San Francisco 49ers in Week 1, the 35 year old Woodson recorded five tackles, 1.5 sacks, and a forced fumble in a losing effort.

[99] Woodson sat out several weeks with the broken collarbone, but made it back for the first playoff game, the Wild Card Round against the Minnesota Vikings.

[115] Prior to Week 5 against the Denver Broncos, Woodson said that he always wanted to intercept a pass from Peyton Manning, as he never accomplished that feat during his career.

[122]On February 12, 2016, it was announced that Woodson would be joining ESPN's Sunday NFL Countdown, replacing Keyshawn Johnson for the upcoming season.

[124][125] Woodson is an oenophile who developed his interest in wine while playing football for the first time in Oakland, near the Napa Valley.

He partnered with former Robert Mondavi winemaker Rick Ruiz to develop a signature wine label, "Twentyfour by Charles Woodson".

In a post-game locker room speech to his teammates, Woodson stated, "The President don't want to come watch us win the Super Bowl?