Charles Wyndham, 2nd Earl of Egremont, PC (19 August 1710 – 21 August 1763), of Orchard Wyndham in Somerset, Petworth House in Sussex, and of Egremont House in Mayfair, London, was a British statesman who served as Secretary of State for the Southern Department from 1761 to 1763.

He was the eldest son and heir of Sir William Wyndham, 3rd Baronet, of Orchard Wyndham, Secretary at War in 1712, Chancellor of the Exchequer in 1713 and Tory leader in the House of Commons during the reign of King George I (1714–1727) and during the early years of King George II (1727–1760).

[1] He succeeded to the Orchard Wyndham estates and as 4th baronet on his father's death in 1740, and in 1750 succeeded by special remainder as 2nd Earl of Egremont, on the death of his maternal uncle Algernon Seymour, 7th Duke of Somerset, 1st Earl of Egremont, and received, as his share of the Seymour inheritance, the former Percy estates, including Egremont Castle in Cumbria, Leconfield Castle in Yorkshire and the palatial Petworth House in Sussex (rebuilt by the 6th Duke[2]).

In October 1761, Egremont was appointed Secretary of State for the Southern Department in succession to William Pitt, 1st Earl of Chatham.

He had progeny including: According to the Encyclopædia Britannica Eleventh Edition, Horace Walpole perhaps rated Egremont's talents too low when he said he had neither knowledge of business, nor the smallest share of parliamentary abilities.