It was created in 1749, along with the subsidiary title Baron of Cockermouth, in Cumberland, for Algernon Seymour, 7th Duke of Somerset, with remainder to his nephews Sir Charles Wyndham, 4th Baronet, of Orchard Wyndham, and Percy Wyndham-O'Brien.
In 1750 Sir Charles Wyndham succeeded according to the special remainder as second Earl of Egremont on the death of his uncle.
He was succeeded by his only son, the third Baronet, a prominent politician who notably served as Chancellor of the Exchequer.
His eldest son was the fourth Baronet, who succeeded as second Earl of Egremont in 1750.
He also sponsored the Petworth Emigration Scheme, which sent thousands of working-class people from the south of England to Upper Canada between 1832 and 1837.