Burie assisted the crown in its efforts to extinguish the embers of the Conspiracy of Amboise in 1560, investigating the situation in Poitiers for the court.

A moderate figure, he looked to find compromise as far as toleration of Protestantism was concerned, conceding the right of Protestants to hold their services in private, and seeking to provide them the right to bury their dead in their own cemetery.

These commissioners proved too partisan, for both Burie and Monluc, who had been assigned to the region to aid in the restoring of order, however before much could be accomplished with their replacements, civil war broke out.

In his office of lieutenant-general, Burie had an important role to play in the control of Guyenne for the crown, and he devoted his efforts to quieting any potential disorder in Bordeaux.

[2] With the situation in much of the north under control, attention turned to the south of France, where much of Guyenne was subject to the uprisings that accompanied the conspiracy.

[7] Burie supported the Protestants of Bordeaux when they complained that the local city authorities had obstructed their efforts to find a burial place for their dead.

En route to assist his deputy, Monluc encountered an envoy from Jeanne d'Albret who assured him she and Burie had the situation under control.

Masparrault and Bourgneuf, commissioners for Saintonge were hoping to investigate the murder of a gentleman in Saint-Jean-d'Angély however Burie refused to offer them the assistance or protection required, so they left the town.