Charles de Lannoy (c. 1487 – 23 September 1527) was a soldier and statesman from the Low Countries in service of the Habsburg Emperors Maximilian I and Charles V. He was a member of the noble House of Lannoy.
He took service with the Emperor Maximilian I and won distinction for bravery and leadership.
He became chief of Imperial armies in Italy upon the death of Prospero Colonna at the end of 1523.
He commanded the Battle of the Sesia (1524), and the siege of Marseille (1524) and Pavia (1525).
He was succeeded by his son Philip de Lannoy, 2nd Prince of Sulmona.