He was drafted in the 11th round by the Seattle Mariners as a senior, but decided to play for his father, Dr. Charles P. Greene, who coached at Miami-Dade College from 1968 to 1996.

[1] Greene entered the MLB in 1996 with the New York Mets, playing for them one year before moving to the Baltimore Orioles (1997–98), Milwaukee Brewers (1999) and Toronto Blue Jays (2000).

Following his MLB career, Greene has played in Triple-A for the Florida Marlins and Tampa Bay Devil Rays organizations.

Greene currently works for the Milwaukee Brewers as their field coordinator and catching instructor.

[3] Charlie's younger brother Mick played Division I basketball at the University of South Florida.