Peguero spent the entire 2018 season with the GCL Yankees, where he made 9 appearances, going 0–3 with a 6.25 ERA and 23 strikeouts.

[3] The Angels assigned him to the Double-A Rocket City Trash Pandas, where he made four appearances, going 1–1 with an 8.44 ERA and eight strikeouts.

He spent the rest of his time with Triple-A Salt Lake, where he registered a 4–1 record and 2.84 ERA with 50 strikeouts and 5 saves in 38 appearances.

[9] On November 22, 2022, the Angels traded Peguero, Janson Junk, and Adam Seminaris to the Milwaukee Brewers for Hunter Renfroe.

[11] He made his Brewers debut against the Boston Red Sox on April 23, where he threw 11⁄3 innings while giving up one hit and striking out two.