He is best known for his role as Dr. Jesse Travis, the resident student of Dr. Mark Sloan (played by Dick Van Dyke) on the CBS series Diagnosis: Murder.

Since the 1990s, he has continued to work mainly as a voice actor, with roles such as the Flash in various media, the titular character on Kick Buttowski: Suburban Daredevil and Wonder-Red in The Wonderful 101.

Schlatter was spotted by a casting director during a performance in 1987 and was asked to audition for Bright Lights, Big City.

He starred in 1988's Heartbreak Hotel (directed by Chris Columbus) where his character kidnaps Elvis Presley in an effort to make his mother (Tuesday Weld) happy.

In late 1995, Schlatter began his role as Dr. Jesse Travis on the television series Diagnosis: Murder, opposite Dick Van Dyke, who was impressed with his performance.

After the series' ending, he and Van Dyke remain close friends, who continues to visit him, Schlatter's wife Colleen and their three children.

In 2014, he appeared as a guest star on the NCIS season 11 episode "Shooter," playing Lorne Davis.

Among his roles were The Flash on Superman: The Animated Series, The Flash on The Batman and Batman Unlimited: Animal Instincts,[5] the title characters in the pilot of Jimmy Two-Shoes, Ace Bunny in Loonatics Unleashed and Kick Buttowski: Suburban Daredevil, Kevin Levin on Ben 10 (not to be confused with Greg Cipes's portrayal in future variations), Hawk on A.T.O.M., Tommy Cadle on Pet Alien, Chris Kirkman on Random!

Cartoons (a character he would later voice in the pilot of Bravest Warriors), Cameron on Bratz and Doctor Mindbender, Wild Bill and Lift-Ticket on G.I.

In 2004, he voiced Aatius Vedrix, Lucius Vulso, Tarakh, Steward Daedakovoon, Znink Flatzazzle and Dunn Coldbrow in EverQuest II.