The series revolves around the chaotic everyday life of a boy named Lincoln Loud, who is the middle child and only son in a large family of 11 children.

Lincoln Loud is the middle child and only boy in a family of eleven children residing in the fictional town of Royal Woods, Michigan.

He has ten sisters, each with a distinctive personality: bossy eldest child Lori, ditzy fashionista Leni, musician Luna, comedian Luan, athletic Lynn Jr., gloomy poetic goth Lucy, polar opposite twins Lana and Lola, child genius Lisa, and baby Lily.

Lincoln often breaks the fourth wall to explain to the viewers the chaotic conditions and sibling relationships of the household, and continually devises plans to make his life in the Loud House better.

In the fifth season, the Loud siblings aged up a year, with Lori entering college, Lincoln going to middle school, and Lily starting preschool.

[8] Early in development, the Loud family was going to be composed of rabbits, but this was terminated when an executive, Jenna Boyd, asked Savino to make them human.

[18] Alongside the announcement of the series being greenlit for a fourth season, it was revealed that story editor Michael Rubiner had now been named executive producer and showrunner.

[27] The Loud House has received positive reviews, specifically for its animation, voice acting, characterization, and the heartwarming themes of each episode.

Ryan Lewis of CBR.com wrote that "Nickelodeon tried too hard to match SpongeBob's influence and immediately took to creating spin-offs, a Netflix movie, and countless merchandise.

"[59] As with other animated series of the decade, The Loud House has been noted for its strong implementation of LGBT themes, including same-sex relationships and people of color.

[61][62] Laura Bradley of Vanity Fair stated that The Loud House "handles the topic [of same-sex marriage] in exactly the right way...this kind of casual representation in children's programming is a milestone.

"[63] De Elizabeth of Teen Vogue wrote, "The best part is that the show doesn't treat these characters any differently, or even introduce them with a heavy asterisk about their marital status.

"[69] Kenya's film and classification board (KFCB) has called for the suspension of several US-produced children's programs running on channels provided by TV company MultiChoice.

The animation programs are The Loud House, The Legend of Korra, and Hey Arnold, which run on the Nickelodeon channel, and Clarence, Steven Universe, and Adventure Time which air on Cartoon Network.

[72] The Los Angeles Times cited The Loud House as a major factor in maintaining Nickelodeon's position as the highest-rated children's network in summer 2016.