She is the daughter of retired professional footballer Claudio Caniggia[2] with retired model Mariana Nannis; her twin brother is Alexander Caniggia, also a media personality.

Her television appearances started in 2010 when she took part, with her mother Mariana Nannis, in Mujeres ricas aired in 2010 by La Sexta in Spain; in 2012[3] she participated in the eight season of the Marcelo Tinelli's Bailando por un Sueño in Argentina; in 2015[4][5] she took part (with Cecilia Rodriguez, Fanny Neguesha, Cristina Buccino, Alex Belli and others contestants) in the tenth season[4][5] of the Italian reality show L'isola dei famosi (Celebrity Survivor Italy)[4][5] hosted by Alessia Marcuzzi with Alvin on Canale 5; in early 2016 she took part in the fourth season of the Spanish reality show Gran Hermano VIP aired by Telecinco: later, in the same year (2016) she participated as a contestant[6] again in the Marcelo Tinelli's dance program, in that year named Bailando 2016 and aired by El Trece.

[7] She hosted, from 18 September 2017 to 29 July 2019, in MTV Latinoamérica her docu-reality programme MTV Caniggia Libre with her twin brother Alexander Caniggia, also a media personality.

In 2019, Charlotte and Alex took part in the Chilean reality show RE$I$TIRÉ and in the same year she took part (alone, without her twin brother) in the Argentinian reality show hosted by Tinelli Showmatch: Super Bailando 2019.

In early 2020 she took part in the Argentinian program Divina comida aired by Telefe;[8] later, in the same year she was a contestant of the Argentinian reality show Cantando 2020 aired by El Trece; in early 2021 she took part in the Acapulco Shore: The family back in Acapulco, a Mexican television programme aired by MTV Latinoamérica; later, during that year (2021), firstly she took part in the Marcello Tinelli's dance program Showmatch: La Academia (aired by El Trece) and secondly, at the end of 2021, in the third season of MasterChef Celebrity (aired by Telefe).