Born in Rome, to father Eugenio, from Trieste, and mother Antonietta from Roseto Valfortore, in the province of Foggia,[1] Marcuzzi debuted on Telemontecarlo hosting Attenti al dettaglio and then Qui si gioca, with José Altafini, in the 1991/1992 season.

[3] In 1994, she also debuted as actress in the movies Chicken Park, directed by Jerry Calà, and Tra noi due è tutto finito.

Marcuzzi started working at Mediaset beginning in November 1995, hosting the Italia 1 Saturday afternoon program Colpo di fulmine, until June 1997.

In 2000, she hosted the pilot of Macchemù, with Paola Barale, dedicated to television themes, and won the Oscar TV as "Personaggio televisivo femminile dell'anno".

She also acted in the TV movie Un amore di strega, with Pietro Sermonti, her partner in 2009, and in the sitcom Così fan tutte, with Debora Villa.