Charlotte Gouffier, Madame de Brissac (born 1482) was a French noblewoman and courtier who served as the Governess of the Children of France.
Gouffier de Boisy was born in 1482 to Guillaume Gouffier, Lord of Boisy and Philippine de Montmorency.
She was the mother of Charles de Cossé, Count of Brissac and the grandmother of Charles II de Cossé, Duke of Brissac.
In 1518 she was appointed as the Governess of the Children of France, a post previously held by Guillemette de Sarrebruck.
As royal governess she was in charge of the education of the children of Francis I of France.