She had previously served as the Chief of Social Policy and Economic Analysis, Planning Monitoring and Evaluation for UNICEF Zambia from 2007 until 2012.

[3] Charlotte and Guy Scott married in 1994 at a wedding held at the Lusaka Civic Centre with the reception at their home in State Lodge.

[1][3] She headed the team which created and launched the Zambian Public Welfare Assistance Scheme, a social protection and poverty alleviation government program.

[5] Scott served as the Chief of Social Policy and Economic Analysis, Planning, Monitoring & Evaluation for UNICEF's Zambian branch for five years from 2007 until 2012.

[3] By 2013, Scott had been appointed a Visiting Fellow of the Institute of Development Studies (IDS) at the University of Sussex.

In 2016, Guy Scott decided would not seek re-election to his Lusaka Central seat in Parliament in the August general election.

[6] Scott and her main opponent, the PF's Margaret Mwanakatwe, were considered the front-runners for Lusaka Central during the election out of the five candidates for the seat.

[8] The attackers, who used stones and screwdrivers to chase Scott and her staff from the market, were supporters of the rival party, the Patriotic Front (PF), according to news reports.

[8] Scott and her staff escaped unharmed, but their Toyota Land Cruiser suffered major damage during the attack.