Christine Kaseba is a Zambian physician, surgeon and politician who served as the First Lady of Zambia from September 2011 until her husband's death in October 2014.

Kaseba made an unsuccessful bid for President of Zambia in the January 2015 special presidential election to succeed her husband.

[2] She filed her nomination papers on November 18, 2014, to contest the January 2015 presidential by-election as a member of Sata's Patriotic Front (PF).

[10] Kaseba was not a member of UPND, but was seen as a potential counter to President Edgar Lungu's running mate, Inonge Wina, who is also a woman, on the presidential ticket.

[10] However, Hakainde Hichilema ultimately chose Geoffrey Bwalya Mwamba as his running mate over Kaseba, Canisius Banda and other potential picks.