Carolinas Medical Center is affiliated with the Wake Forest School of Medicine.

[2][full citation needed] Dr. Francis Robicsek performed the first heart transplant at Carolinas Medical Center in 1986.

[4] Students from UNC School of Medicine had been completing clinical rotations at Carolinas Medical Center for over 40 years prior.

[5] In October 2020, Wake Forest School of Medicine and Atrium Health began an agreement to make Carolinas Medical Center one of its flagship teaching hospitals along with the creation of a Charlotte campus of its medical school.

[7] Today, Carolinas Medical Center is the region's only Level 1 Trauma Center and part of Atrium Health, one of the largest public not-for-profit healthcare systems in the United States.