[5] As a teenager, Nichols had one of her earliest experiences of politics when she helped run after-school UK Youth Parliament activities with future Conservative Prime Minister Theresa May.

[8] Nichols then went on to work for the GMB trade union as a national research and policy officer,[9] where she campaigned for better term and conditions for Amazon and Asda workers.

[15] Nichols supported Rebecca Long-Bailey in the 2020 Labour Party leadership election, but nominated Emily Thornberry to broaden the field of candidates.

[21] Prior to the December 2019 general election, Nichols authored an article on the website LabourList defending Jeremy Corbyn's attendance at a Passover Seder organised by Jewdas.

[23] In October 2019, Nichols tweeted that supporters of the football club SS Lazio, filmed making Nazi salutes in Glasgow, should "get their heads kicked in."

Defending her comments in December of the same year, Nichols stated, "These were people doing Nazi salutes on the streets of Britain... As a Jewish person whose grandfather fought in World War Two, ultimately sometimes I believe that fascism has to be physically confronted.

"[24][25] An article published in The Daily Telegraph in 2019 reported that Nichols had described members of the Green Party as "bourgeois scab fucks" and told one Twitter user, "Hope you lose your virginity".

At the age of 22, she began attending weekly services at the Manchester Reform Synagogue, describing the experience as bringing her a sense of peace she had not previously felt.