Throughout her career, she has worked with different types of music, ranging from dansband and schlager, via modern pop, to soulful ballads and jazz melodies.

[5] From 1997 to 1998 Nilsson starred as the instructor Millan Svensson in the Swedish soap opera Vita lögner.

[4][7] She won the contest with 163 points, making her the fourth Swedish representative to win the competition since Carola Häggkvist's victory in 1991, the Herreys brothers' in 1984 and ABBA's in 1974.

[8][9] Following her Eurovision success, Nilsson toured Europe and the Middle East, promoting her winning song.

[22] In 2006, she released the album I din röst, in honour of the famous jazz singer Monica Zetterlund, which covered Zetterlund's most famous songs, along with some personal favorites and the soul ballad "I din röst", the title song written by Perrelli for the album.

[23] The album was successful, and she performed many of the songs in Sweden's top shows such as Allsång på Skansen and Nationaldagen.

She also co-hosted the TV show Tillsammans för världens barn in October, where she also performed "The Greatest Love of All".

[24] In May 2007 Perrelli was the Swedish expert in the Nordic preview show panel discussion about the Eurovision Song Contest.

She was joined by singers such as Linda Bengtzing, Lasse Holm, Molly Sandén, Lotta Engberg and Jan Johansen.

[27] During the autumn she released the single disco song "Jag är tillbaks" which she performed at the show Babban & Co.[28] On 15 March 2008, Perrelli performed at the Stockholm Globe Arena and won Melodifestivalen 2008 again with her song "Hero",[29] which topped the charts in Sweden for several weeks and became the most sold single of 2008 for a Swedish artist.

Preparing for Eurovision, she went out on a big tour, performing at popular TV shows in 17 nations, in order to promote the song.

[38] Perrelli recorded a new single for the Swedish Royal Wedding in June 2010 together with pop singer Magnus Carlsson titled "Mitt livs gemål", which was very well received and performed throughout Sweden.

In November 2011, she confirmed that she would play Eva Peron in the Swedish version of the musical Evita at the Malmö Opera.

She participated in Melodifestivalen 2012 with the entry "The Girl" by Fredrik Kempe in a bid to represent Sweden at the Eurovision Song Contest 2012 in Baku, Azerbaijan.

[43] Nonetheless, she released her seventh album titled The Girl, which contained eight new tracks, including "Little Braveheart", a duet with Belgian singer Kate Ryan.

[53][54] Perrelli performed as one of the interval acts in the second semi-final and final of the Eurovision Song Contest 2024 in Malmö.

[55][56] In August 2003 in Oscar's Church, Charlotte Nilsson married Stockholm-based Swedish–Italian restaurateur Nicola Ingrosso, her partner since 1996.

[57] Much of Ingrosso's family boycotted the wedding amid a dispute that prompted Nicola and Charlotte to change their surnames to Perrelli, his mother's maiden name.

After speculation in Swedish media that the couple were experiencing relationship issues, Perrelli and Ingrosso officially announced their separation in June 2008.