The marriage, which had taken place without the consent of the French king,[3] was Louis' second; his first spouse, Margaret of Scotland, had died childless in 1445.

He had Queen Charlotte and her household kept secluded at the Château of Amboise, where she spent her days with her sisters and courtiers, supervising the education of her daughters (her son was educated by the king), playing chess and marbles, listening to her lute player, doing needlework and fulfilling her religious duties.

On rare occasions, she was asked to fulfil ceremonial tasks as queen such as greeting foreign guests, for example in 1470, when the king took the powerful Earl of Warwick and the Duke of Clarence from England to Amboise to visit her.

A contemporary noted that "while she was an excellent Princess in other respects, she was not a person in whom a man could take any great delight";[2] However, after the birth of her last child in 1472, Louis swore that he would no longer be unfaithful, and according to the chronicler Phillip de Commynes, he kept this vow.

Charlotte was widowed on 30 August 1483, upon which Louis XI was succeeded by their son Charles VIII, who was still a minor.

Louis XI did not make Charlotte regent if his son should succeed him while still a minor; he did in fact not formally appoint a regent at all, but he did leave instructions for a royal council to govern during such a minority, in which Charlotte, alongside Duke Jean de Bourbon II and their two sons-in-law Louis d'Orleans (married to their daughter Jeanne) and Peter II, Duke of Bourbon (married to their daughter Anne), were made members.