The road originally ran from Signal Hill to Hung Hom, under No.

It was later extended through Lo Lung Hang to the southern end of To Kwa Wan, which makes up Chatham Road North.

transferred to a series of Des Voeux Road newly completed along the north shore of Hong Kong Island.

Conventionally locals take Chatham Road South as the dividing line between Tsim Sha Tsui and Tsim Sha Tsui East.

It feeds into the East Kowloon Corridor at its northern end, forming a section of Hong Kong's Route 5.