The road was laid out after 1901 and named after William Julius Gascoigne,[2] Commander British Troops in China and Hong Kong from 1898–1903.

"[3] The Fronde Memorial, a granite obelisk, was erected in May 1908 in memory of the five sailors of the French Arquebuse-class destroyer Fronde who disappeared in the sinking of their boat near the Torpedo Depot, Kowloon, during the 1906 Hong Kong typhoon.

[5] The Fronde was later salvaged, repaired in the Hung Hom shipyard, and left Hong Kong in March 1907.

[6] Gascoigne Road was widened in 1988 and the adjacent slope near the Queen Elizabeth Hospital was cut back.

A 12m high rock-socketed caisson retaining wall was constructed to support the cutting.