Chauffailles (French pronunciation: [ʃofaj]) is a commune in the Saône-et-Loire department in the region of Bourgogne-Franche-Comté in eastern France.

Chaufailles lies in the extreme south of the department of Saône-et-Loire at the foot of the Beaujolais mountains.

Chauffailles was the base of the Congrégation des Soeurs de l'Enfant-Jésus de Chauffailles, an order of teaching nuns founded by Reine Antier (1801–83).

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