The family is first attested in the 15th century, during the reign of Alexander I of Georgia.
Both these lines were elevated to a princely dignity under the kings Erekle I (1680s) and Constantine II (1726), respectively.
The Chavchavadze family, with its head Prince Garsevan, came to much prominence under the king Erekle II later in the 18th century, and continued to play an important role in Georgia during the Imperial Russian rule.
On 4 July 1853, a small party under Ghazi Muhammad (the son of Murid leader, Imam Shamil) kidnapped Prince Chavchavadze's wife Anna and his sister-in-law, Princess Varvara Orbeliani, together with their children and some others.
The princess was exchanged for Shamil's son, Jamalu'd-din and 40,000 roubles on 10 March 1855.