Towns are marked in bold: Aš - Cheb - Dolní Žandov - Drmoul - Františkovy Lázně - Hazlov - Hranice - Krásná - Křižovatka - Lázně Kynžvart - Libá - Lipová - Luby - Mariánské Lázně - Milhostov - Milíkov - Mnichov - Nebanice - Nový Kostel - Odrava - Okrouhlá - Ovesné Kladruby - Plesná - Podhradí - Pomezí nad Ohří - Poustka - Prameny - Skalná - Stará Voda - Teplá - Třebeň - Tři Sekery - Trstěnice - Tuřany - Valy - Velká Hleďsebe - Velký Luh - Vlkovice - Vojtanov - Zádub-Závišín Cheb District borders Germany in the west.

It includes the Aš Panhandle area, which makes it the westernmost district of the Czech Republic.

The relief is very varied and includes both flat plains and hilly areas with relatively high altitudes.

The highest point of the district is the mountain Lesný in Dolní Žandov with an elevation of 983 m (3,225 ft).

The largest employers with headquarters in Cheb District and at least 500 employees are:[5] The D6 motorway from Prague to Karlovy Vary and Cheb (part of the European routes E48 and E49) forks and continues to the Czech-German border to the west (as E48) and to the north (as E49).