[2][3][4] In January 1889, in Greenville, Pennsylvania, Henry Hoffman, George Smith, and Teddy Atkins participated in a cheese sandwich eating contest.

[11][12] In response, in 2015, Anchor Cheddar launched a campaign using a bus designed to look like a cheese sandwich to encourage the consumption of this classic food.

[17] In 2008, the Food Standards Agency warned that a cheese sandwich contains more than half the recommended daily amount of saturated fat.

The group reported that the high quantities of salt in the main ingredients of a cheese sandwich could lead to children consuming an excessive amount.

[26][27] In the 2001 film Freddy Got Fingered, the main character, Gord (played by Tom Green), works at a cheese sandwich factory.