It is notable for its main theme, as it was later used as the overworld music in Cat Mario, as well as its extremely low quality, often being cited as one of the worst video games of all time.

A man called the "Action Gamemaster" is depicted in the first Cheetahmen game's intro sequence, which serves as a framing device.

The man is shown playing a video game when he is abruptly pulled into his television by a robotic arm and meets the Cheetahmen.

Subjected to genetic experimentation, the cubs transform into human-cheetah hybrids who eventually turn on Dr. Morbis after gaining awareness of his true nature and future plans.

Dr. Morbis responds by creating an army of various human-animal hybrids (known as "Sub-Humans") to counter the threat posed by the self-aware Cheetahmen.

Most of in-game enemies are characters from the other games of the Action 52 cartridge, including Satan Hosain, a parody of former president of Iraq Saddam Hussein.

[1] Subsequently, a "fixed" version of the game titled Cheetahmen II: The Lost Levels was developed by Greg Pabich.

Features would have included a 3.2" color LCD screen, CD player, TV tuner, built-in battery charger, and a cigarette-lighter adapter for cars.