Born in the colonia of La Experiencia in the city of Zapopan, Jalisco, Chelo is the cousin of Mike Laure, another cumbia recording artist.
Chelo and her daughter Yesenia Flores formed a whole era which leads them to sing throughout Mexico, Central and South America, Canada, as well as throughout the United States.
They traveled around the world in great artistic caravans with figures such as Juan Gabriel, Vicente Fernandez, Lola Beltran, Lucha Villa, among others.
Her most successful hit songs are "Mejor Me Voy", "Que Sacrificio", "Dos Gotas De Agua", "Al Ver Que Te Vas", "Las Cuentas Claras", "Si Ya Te Vas", "Ya Me Voy", and "Volverás Por Mi" (which reached number 1 on Billboard's Mexican Top Ten list).
Chelo and Yesenia venture into the cinema with films such as: Emilio Varela & Camelia la Texana, Contrabando Humano, De Puro Relajo, Operacion Mariguana, and Aborto.