The first location was on Ashbourne Road, and at the time of its closing in 1953, it was considered the oldest public school site in continuous use.

They have a long-standing tradition of holding a Thanksgiving Day football game against their cross-town rival, Abington Senior High School.

Among the school's notable alumni are the Prime Minister of Israel Benjamin Netanyahu, his older brother Yoni Netanyahu, Yoni's class of 1964 classmate baseball Hall of Famer Reggie Jackson, talk radio host Mark Levin, 15-time Grammy Award winner Michael Brecker, and rapper Lil Dicky.

In 2004 the school adopted a stricter dress code because the administration felt that clothing that was too loose could hide identity badges and make identifying occupants more difficult.

[4] Cheltenham Township School District offers a wide variety of clubs, activities and an extensive sports program.

CHS is a member of the Pennsylvania Interscholastic Athletic Association (PIAA) and in the Suburban One American Conference (SOL).

"[9] The award is given to individuals or teams who have "represented the Philadelphia area with dignity, determination, and class through athletic achievement.

They have also won seven PIAA District 1 championships (2013 - 2019)[13] The Cheltenham–Abington rivalry, also known as "The Turkey Bowl", is a football game played between the Cheltenham Panthers and the Abington Galloping Ghosts.

Other activities include the Touring Ensemble, CHS's show choir, in which students prepare a set of song and dance numbers-often with a central theme-and perform monthly around the community as well as at competitions.

The Cheltenham High School Hall of Fame was established to "acknowledge the achievements of our alma mater's most remarkable graduates".