Chemillé-sur-Dême (French pronunciation: [ʃəmije syʁ dɛm]) is a commune in the Indre-et-Loire department in central France.

[3] The commune is situated in the Western area, near the borderline of the Sarthe region and Loir-et-Cher in the Indre-et-Loire department in central France.

It is bordered by other communes such as, Épeigné-sur-Dême, Villedieu-le-Château, Montroveau, Les Hermites, Marray, Louestault and Neuvy-le-Roi.

The commune is known to have clayey soils in most parts which result in minor cases of shrinkage / swellage, negatively impacting some buildings, and infrastructure.

• Jean Raspail, French writer and explorer born in the commune in 1925, who died in Paris in 2020.