[11] As of the census of 2020,[15] there were 5,199 people, 2,272 households, and 1,271 families residing in the city.

There were 2,498 housing units at an average density of 369.7 per square mile (142.8/km2).

Hispanic or Latino persons of any race comprised 6.6% of the population.

38.8% of all households were made up of individuals, 20.4% had someone living alone who was 65 years old or older.

At the 2010 census there were 5,253 people in 2,316 households, including 1,339 families, in the city.

At the 2000 census there were 5,369 people in 2,362 households, including 1,393 families, in the city.

Findings here have helped to redefine the Archaic period in the Midwest.

The Phipps Site is a 1000-year-old indigenous Plains farming village, which may have been fortified.

The annual Jazz Festival is held in January, often headlined by Mark Pender, a member of the Basic Cable band.

Past performers include Kid Rock, The Band Perry, Big & Rich, and Florida Georgia Line.

[20] Cherokee is the home of the Sanford Museum and Planetarium that opened in 1951.

Sanford, intended to create a museum that was free and open to the public.