Stan, worried about the inevitable loss of his best friend, decides to take matters into his own hands and get Cartman's kidney to save Kyle's life.
They visit the holistic medicine store of a newly arrived shopkeeper named Miss Information, who tells them that mysterious "toxins" are the cause of Kyle's ailments and prescribes a series of herbs to help him; they do not help, but she convinces the people of South Park that they are healing him even though it is not visible.
The whole town becomes enamored with her remedies and buys such nostrums as "Cherokee hair tampons" from two supposed Native Americans (played by Cheech Marin and Tommy Chong) who share her store.
Before long, everyone is so hooked on "holistic medicine" that Miss Information can get away with selling coat hangers as "dream catchers" for very high prices.
The two Mexicans reveal to the townsfolk that Miss Information is a fraud who convinced everyone that they were Native Americans and that they had simply neglected to set the record straight.
Furious of being scammed, the townsfolk attack and beat Miss Information to death, and Stan declares that he has a plan to get Kyle a kidney.
Infuriated, he marches to Stan's house and recovers his kidney, then goes to the doctor and arranges to have it put back in, but not before signing a release form.
Cartman is angered, Kyle is better, and Mr. Garrison - now a best-selling author - comes to give him a signed copy of his book, In the Valley of Penises.