The fourth season of South Park, an American animated television series created by Trey Parker and Matt Stone, began airing on April 5, 2000.

As explained in the FAQ section on the official website: "When the year 2000 was coming up, everyone and their brother had '2000' in the titles of their products and TV shows.

America was obsessed with 2000, so Trey Parker put '2000' in the titles to make fun of the ubiquity of the phrase.

[3][4] This is the first season to feature Eliza Schneider and Mona Marshall as series regulars, who would go on to provide many of the female voices on the show.

Stan must get Cartman to donate one of his kidneys to save Kyle's life when everyone in town is addicted to new-age medicine run by an old woman and her "Native American" co-workers.