Cherokee Middle School was located at the eastern limits of Cherokee, Alabama on the north side of County Road 20.

It served the children of western Colbert County for grades 5 through 8.

The decline of population in the western portion of the county caused the school to close at the end of the 2006 – 2007 school year and the grades merged into Cherokee High School and Cherokee Elementary.

At that time the segregated school for “white” children was named Cherokee Vocational High School.

[2] After the original junior high school building (located on the Cherokee Vocation High School campus) burned in January 1971 Cherokee Middle School began handling grades 5 through 8.