Cherokee Pass is an unincorporated community and census-designated place in Madison County, Missouri, United States.

Cherokee Pass is located on U.S. Route 67 in central Madison County, approximately 5 miles (8 km) south of Fredericktown, the county seat, and 25 miles (40 km) north of Silva.

The community sits at an elevation of 978 feet (298 m) on the height of land between north-flowing tributaries of the Little St. Francis River and south-flowing Twelvemile Creek; both waterways are tributaries of the St. Francis River.

According to the U.S. Census Bureau, the Cherokee Pass CDP has an area of 2.09 square miles (5.41 km2), of which 0.01 square miles (0.03 km2), or 0.52%, are water.

This Madison County, Missouri state location article is a stub.