He was out of the mare Cherokee Dame, who is the daughter of Silver Saber, and Dame Franchesca who was by Frincis S. Onett popularized nicking to Nearco as with Cherikee Fellow and Groomstick wall with heavy traces directly back to Nearco, War Admiral, and Tom Fool.
Even though he is the offspring of two grey colored horses, Cherokee Run was born with a black coat and a white splash on the forehead just like his grandmother Dame Franchesca.
Cherokee Run was retired in 1996 and stood at Jonabell Farm in Lexington, Kentucky, for a fee of $40,000 live foal.
Some of his offspring are War Pass, Chilukki, Kafwain, Zanjero, Madame Cherokee, During, Recapturetheglory, Balraj, and Dash for Daylight.
Chedi, a 2007 Virginia bred gelding, out of Doctoressa (Doc's Leader), set a new track record at Colonial Downs on July 6, 2011, going 1 mile in 1:34.3.