He is most often remembered for the Roman frescoes completed with his brother Giovanni Alberti during the papacy of Clement VIII.

[1] Alberti was born in 1553 in Borgo San Sepolcro, Tuscany (from which he took his nickname of Borgheggiano), into family of artists.

Over the next ten years his engravings included works after Raphael, Michelangelo, Polidoro da Caravaggio, Andrea del Sarto, Rosso Fiorentino, Marco Pino, Pellegrino Tibaldi, and Cristofano Gherardi.

His most famous work was the fresco decoration of Sala Clementina in the Vatican, which he completed with his brother Giovanni.

At his death in Rome Alberti was Director of the Academy of Saint Luke, an association of artists.